For volunteers
What is a clinical trial?
A clear, no-pressure explanation of how research works and what taking part actually looks like.
The basics
A clinical trial is a carefully designed research study that looks at how an investigational medication, vaccine, or device behaves in people. Every trial follows a written plan called a protocol, which defines who can take part, what happens at each visit, and what information is collected.
Trials are not treatment. The purpose is to answer a research question, and no one can promise a personal health benefit from taking part.
Study phases
Research typically moves through four phases. Phase I studies focus on safety in a small group. Phase II looks at how a treatment behaves in people with the condition. Phase III involves larger groups and comparison arms. Phase IV takes place after approval to gather longer-term information.
Your rights
You will always receive an informed consent document before anything study-related happens. You can ask questions, take it home, discuss it with your family or physician, and decline. You may withdraw at any time, for any reason.
- Participation is always voluntary
- You may withdraw at any time without penalty
- Your information is handled confidentially
- You are told about new information that could affect your decision
Frequently asked questions
Answers to questions we hear most often.
What is a clinical trial?
A clinical trial is a research study that evaluates an investigational medication, vaccine, or device in people, following a written protocol reviewed by an Institutional Review Board.
What are trial phases I through IV?
Phase I evaluates safety in a small group. Phase II examines how the treatment behaves in people with the condition. Phase III studies larger groups with comparison arms. Phase IV takes place after approval.
What is informed consent?
Informed consent is a process, not just a signature. The study team explains the purpose, procedures, risks, and alternatives, answers your questions, and gives you time to decide before you sign anything.
Is participation safe?
Every study carries some risk, and those risks are described in the consent document. Protocols are reviewed by an IRB, and the study team monitors participants throughout for safety.
Will I be paid or reimbursed?
Many studies offer compensation for time and travel. Amounts vary by protocol and are described in the informed consent document before you enroll.
Can family members join too?
Family members may participate if they independently meet the eligibility criteria of a study. Each person consents separately.
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View enrolling studiesInformation on this website is provided for general educational purposes about clinical research and is not medical advice. Participation in any study is voluntary.